Bret & Heather DarkHorse Podcast Livestream 59: 2020 Jumped the Shark But Will We Stick the Land

10 Jan 2021

In this 59th in a series of live discussions with Bret Weinstein and Heather Heying (both PhDs in Biology), we discuss the state of the world through an evolutionary lens. In this episode, we discuss the CDC recommendations to engage in race-based vaccine distribution, the New England Journal of Medicine jumping the shark on sex and birth certificates, and the role of markets in journalism. We also pay attention to this moment in time: Chanukah, Christmas and the solstice, plus a reading from Dickens’ A Christmas Carol. We begin the episode by making a few corrections from episode 58, on the subjects of ligands and adaptive immunity.

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Theme Music: Thank you to Martin Molin of Wintergatan for providing us the rights to use their excellent music.

Q&A Link:

Mentioned in this episode:

Hirano et al 2011. The Evolution of Adaptive Immunity in Vertebrates, chapter 4 in Advances in Immunology. Frederick W. Alt, Ed. Academic Press, 109(2011): 125-157.

The New York Times on racializing vaccine distribution:

The CDC’s November 23, 2020 slidedeck originally arguing for this:

Shteyler, V.M., Clarke, J.A. and Adashi, E.Y., 2020. Failed Assignments-Rethinking Sex Designations on Birth Certificates. The New England journal of medicine.

Ferretti et al. 2018. Sex differences in Alzheimer disease — the gateway to precision medicine. Nature Reviews Neurology 14: 457–469.

Vetvik, K.G. and MacGregor, E.A., 2017. Sex differences in the epidemiology, clinical features, and pathophysiology of migraine. The Lancet Neurology, 16(1): 76-87.

Lynch, W.J., Roth, M.E. and Carroll, M.E., 2002. Biological basis of sex differences in drug abuse: preclinical and clinical studies. Psychopharmacology, 164(2): 121-137.

Szewczyk-Krolikowski, K., Tomlinson, P., Nithi, K., Wade-Martins, R., Talbot, K., Ben-Shlomo, Y. and Hu, M.T., 2014. The influence of age and gender on motor and non-motor features of early Parkinson's disease: initial findings from the Oxford Parkinson Disease Center (OPDC) discovery cohort. Parkinsonism & related disorders, 20(1): 99-105.

See, e.g.: Allen, J.S., Damasio, H., Grabowski, T.J., Bruss, J. and Zhang, W., 2003. Sexual dimorphism and asymmetries in the gray–white composition of the human cerebrum. Neuroimage, 18(4): 880-894.

Ingalhalikar, M., Smith, A., Parker, D., Satterthwaite, T.D., Elliott, M.A., Ruparel, K., Hakonarson, H., Gur, R.E., Gur, R.C. and Verma, R., 2014. Sex differences in the structural connectome of the human brain. Proceedings of the National Academy of Sciences, 111(2): 823-828.

Charles Dickens’ A Christmas Carol:

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